Welcome to the chromosome segregation laboratory at the marie curie research institute. We use a combination of quantitative cell biology and in vitro reconstited biochemical systems to investigate the fundemental mechanisms of chromosome segreagation in human cells.

We are particulary interested in kinetochores - amazing multi-protein machines that link chromosomes to the dynamic plus-ends of spindle microtubules.

info| what is a chromosome? - find out more here

info| what is a kinetochore? - find out more here

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4th Mar 09| Fireworks! Marcus Braun has revealed that the kinesin-14, Klp2, can actively sort microtubules into paralell bundles

e-print (Nature Cell Biology)

9th Feb 09| Push Push! Jennifer Winter & Alberto Toso discovered that kinetochores can generate forces to "push" centrososmes apart.

e-print (Journal of Cell Biology); research highlight (Nature Reviews Molecualr Cell Biology)

3rd Feb 09| Marcus has now left the lab - off to a postdoc position in Dresden at the MPI with Stefan Dietz...very sad that everyone leaves but, also really good that they find exciting things to do in Science!